Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp111 | Diabetes Translational | ECE2018

Olfactory receptor OR51E1 mediates GLP-1 secretion in enteroendocrine L cells

Ku Cheol Ryong , Han Ye Eon , Kim Daham , Hong Jae Won , Kim Sun Ho , Lee Eun Jig

Few studies have investigated the intracellular signaling pathways mediating the effects of glucagon-like peptide-1 (GLP-1) secretagogues in enteroendocrine L cells. Specific receptors, channels, and intracellular signaling proteins expressed by the L cells have only begun to be characterized. The present study aimed to investigate the role of the olfactory receptor (OR) OR51E1 in GLP-1 secretion. We verified the expression of olfactory marker protein (OMP), an indicator of OR...